ABSTRACT
Selected monoclonal antibody molecules were conducted using the antibody-antigen docking mode, as well as the antibody-antigen docking approach. The objective of the study was to check the effects of Cetuximab COVID-19 proteins (Nsp15 and 3CLpro) by using antibody-antigen docking mode, as well as the antibody-antigen docking approach. The results of molecular docking revealed that Cetuximab, a cancer-fighting antibody, ranks first among antibodies to both COVID-19 proteins (Nsp15 and 3CLpro). In cetuximab-3CLpro and cetuximab-Nsp15 complexes, the antigen interacts with both antibody chains, H and L. According to the findings, Cetuximab can be added to the COVID-19 treatment protocol, which may have the desired effect of inhibiting viral replication and decreasing mortality by targeting COVID-19 proteins (Nsp15 and 3CLpro). Validation of these computational findings will require additional in vitro and in vivo research, which can be considered as a contribution in the field of biotechnology © 2023, Physical Chemistry Research.All Rights Reserved.
ABSTRACT
The coronavirus disease (COVID-19) pandemic has been caused by the worldwide infectious spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its mechanism of action involves RNA virus implantation into the cell’s cytoplasm and the hijack of transcriptional machinery. The infection primarily afflicts the pulmonary system, resulting in multiple complications including, but not limited to, ground glass opacities seen on imaging. Characteristic features of COVID-19 involve pneumonia, shortness of breath, asthma, nasal congestion, sore throat, fever, fatigue, myalgia and it also encompasses a wide variety of other systemic symptoms. Multiple pharmaceutical agents have been tried as a treatment for COVID-19 but the results are inconsistent. With the intention of stopping person-to-person transmission, health measures such as quarantine and social distancing have been adopted, but the implementation was difficult. After the first wave of the pandemic, the second wave surfaced with a clear resurgence of cases followed by a third wave. The present review summarizes what is known about COVID-19 and explores the factors behind the resurgence.
ABSTRACT
Just in a week a rapidly spreading corona virus which was originated in Wuhan, city of China, infected more than 20,000 people and also killed at least 427 people in that week worldwide. Corona virus is transmissible and spreading from person to person, while the Chinese commanded authorities are scrambling to treat a flood of new patients in Chines successfully. The said Corona virus has been spread from an initial outbreak in Wuhan, city of China, and invade 25 other worldwide countries. In this article, we considered the mathematical model (Chen et al. Infect Dis Poverty, https://doi.org/10.1186/s40249-020-00640-3) in which Bats-Hosts-Reservoir-People and their transmission was taken, while we introduced the population of susceptible Bats and visitors to Wuhan city or any country in same mathematical model. Now we studying two types of populations first Bats-Hosts-Reservoir-People (Chen et al. Infect Dis Poverty, https://doi.org/10.1186/s40249-020-00640-3, also introducing susceptible Bats and second visitors to Wuhan city, china or any country in the same model. We used Caputo-Fabrizio derivative with provided result that the addition of susceptible Bats and visitors are not responsible in spread of infection. The numerical result also supported our model. © 2020, The Author(s).